Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways

Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways

Blog Article

The Golgi apparatus is a central hub for cellular protein trafficking and signaling.Golgi structure and function is tightly Spray Scanner3D coupled and undergoes dynamic changes in health and disease.A crucial requirement for maintaining Golgi homeostasis is the ability of the Golgi to target aberrant, misfolded, or otherwise unwanted proteins to degradation.

Recent studies have revealed that the Golgi apparatus may degrade such proteins through autophagy, retrograde trafficking to the ER for ER-associated degradation (ERAD), and locally, through Golgi apparatus-related degradation (GARD).Here, we review recent discoveries in these mechanisms, highlighting Nets the role of the Golgi in maintaining cellular homeostasis.